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Search Results for " lung adenocarcinoma "

17

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T23372	SMIFH2	Others	Others
	SMIFH2 是formin 特异性抑制剂。它利用 Formins 阻碍肌动蛋白聚合，影响肌动蛋白细胞骨架。
T8320	J14 J-14	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	J14 是一种可逆的 sulfiredoxin 抑制剂，IC50=8.1 μM。它能够抑制sulfiredoxin 诱导氧化应激，使细胞内ROS 积累，导致细胞毒性和癌细胞死亡。
T9891	PARP1-IN-8 N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) 是PARP1的有效抑制剂（IC50 = 97 nM）。
T15558	GSK319347A	IκB/IKK	NF-κB
	GSK319347A 是一种具有选择性和有效性的 TBK1 和 IKKε 的双重抑制剂，具有潜在的抗肿瘤活性，对 IKK2 活性有抑制作用，可用于研究膀胱癌和肺腺癌。
T62281	PARP-1-IN-2	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP-1-IN-2 是一种有效且可透过血脑屏障的 PARP1 抑制剂（IC50： 149 nM）。PARP-1-IN-2 在细胞实验中对人肺腺癌上皮细胞系 A549 显示出显著的抗增殖活性。PARP-1-IN-2 可诱导 A549 细胞凋亡。
T60446	LCS3	Apoptosis; Glutathione reductase	Apoptosis; oxidation-reduction
	LCS3是一种可逆和非竞争性的谷胱甘肽二硫化物还原酶（GSR）和硫氧还蛋白还原酶1（TXNRD1）的协同抑制剂，IC50分别为3.3μM 和3.8μM。LCS3具有抗肿瘤活性，可诱导细胞凋亡，可用于研究肺腺癌（LUAD）。
T11793	KY-05009	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KY-05009 是 ATP 竞争性的、有效的 TNIK 抑制剂，Ki 为 100 nM。KY-05009抑制人肺腺癌细胞中 TGF-β1 诱导的上皮-间质转化。KY-05009 还抑制TNIK 的蛋白表达和Wnt 靶基因的转录活性，并诱导癌细胞凋亡，显示抗癌活性。
T76873	Nidanilimab CAN04	IL Receptor	Immunology/Inflammation
	Nidanilimab (CAN04) 是一种完全人源化的 IL1RAP 单克隆抗体，其 Kd 值为 1.10 pM。Nidanilimab 具有抗肿瘤活性，切断 IL1α 和 IL1β 信号通路，并诱导免疫系统破坏肿瘤细胞。Nidanilimab 可用于研究非小细胞肺癌 (NSCLC) 和胰腺导管腺癌 (PDAC) 等实体癌。
T71060	IST-622
	IST-622 is a unique topoisomerase inhibitor, showing significant growth-inhibitory effects against large-cell lung cancer (Lu-116) and gastric adenocarcinoma (St-4).
T10588	BPI-9016M	Others	Others
	BPI-9016M is an effective, orally active, and selective dual inhibitor of c-Met and AXL tyrosine kinases. It suppresses tumor cell growth, invasion, and migration of lung adenocarcinoma.
T61806	Antitumor agent-44
	Antitumor agent-44 (Compound 5n) elicits potent antitumor effects by inducing disruption of mitochondrial homeostasis, cell cycle arrest, and apoptosis in human adenocarcinoma cells. Moreover, Antitumor agent-44 demonstrates significant anti-tumor activity in a lung cancer cell xenograft mice model [1].
T38302	Chrysomycin B
	Chrysomycin B 是分离自链霉菌的一种抗生素。Chrysomycin B 能引起人肺腺癌 A549 细胞系的 DNA 损伤，并抑制拓扑异构酶 II。
T82605	DB21, Galectin-1 Antagonist	Galectin	Immunology/Inflammation
	DB21, Galectin-1 Antagonist 是一种用于抑制galectin-1 (GAL1)与细胞表面聚糖结合的二苯并呋喃缀合肽模拟物。在黑色素瘤、肺腺癌和卵巢癌模型中，该化合物能增强血管生成和肿瘤生长的抑制效果。
T35729	Nemadipine-A
	Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It ...
T36454	1-Stearoyl-rac-glycerol
	1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid at the sn-1 position. 1-Stearoyl-rac-glycerol levels are decreased in tumor tissue in a mouse model of azoxymethane-induced colorectal carcinogenesis. Levels of 1-stearoyl-rac-glycerol are decreased in lung tissue from patients with adenocarcinoma, but are increased in the serum of patients with Buruli ulcer and in the cerebrospinal fluid of patients with the inflammatory demyelinating diseases multiple sclerosis (MS), neur...
T62510	Antitumor agent-75
	Antitumor agent-75 是一种新型的、有效的抗肿瘤剂。Antitumor agent-75 对癌症和正常人类细胞系具有细胞毒性作用。Antitumor agent-75 结合使用 Antitumor agent-74 时对人肺腺癌（细胞系 A549 ）表现出高度选择性的细胞毒作用 (IC50: 2.8 μM)。Antitumor agent-75 能够用于研究癌症。
T36846	Chromomycin A2
	Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of B. subtilis in an agar diffusion assay. It also inhibits the growth of human SGC7901 gastric cancer, HepG2 hepatocellular carcinoma, A549 lung epithelial adenocarcinoma, HCT116 colon cancer, and COC1 ovarian cancer cells, as well as human umbilical vein endothelial cells (HUVECs; IC50s = 4, 0.5, 3, 5, 5, and 8 nM, respective...

化合物

Cat.No: T23372

Target: Others

Cat.No: T8320

Synonym: J-14

Target: Reactive Oxygen Species

Cat.No: T9891

Synonym: N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide

Target: PARP

Cat.No: T15558

Target: IκB/IKK

Cat.No: T62281

Target: PARP

Cat.No: T60446

Target: Apoptosis, Glutathione reductase

Cat.No: T11793

Target: Wnt/beta-catenin

Cat.No: T76873

Synonym: CAN04

Target: IL Receptor

Cat.No: T71060

Cat.No: T10588

Target: Others

Antitumor agent-44

Cat.No: T61806

Cat.No: T38302

DB21, Galectin-1 Antagonist

Cat.No: T82605

Target: Galectin

Cat.No: T35729

1-Stearoyl-rac-glycerol

Cat.No: T36454

Antitumor agent-75

Cat.No: T62510

Cat.No: T36846

Cat. No.	Product Name	Target	Signaling Pathways
TN5086	Syringetin	Others	Others
	Syringetin 是一种存在于葡萄和葡萄酒中的类黄酮衍生物，可促进 B16F10 细胞的黑色素生成，抑制人肺腺癌中成骨细胞介导的破骨细胞生成。
TN2347	Methylsticin 麻醉椒苦素,Methysticin	Others	Others
	Methylsticin (Methysticin) 是一种卡瓦内酯，从卡瓦根中分离得到。它能够抑制破骨细胞形成的活性。
T1660	Silibinin 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I	Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Silibinin (Silybin) 是水飞蓟的主要活性成分，具有抗癌和化疗预防作用，能抑制细胞增殖和迁移。
TN5274	Yunnancoronarin A	Others	Others
	Yunnancoronarin A shows cytotoxicity against the lung adenocarcinoma cells A549 and leukemia cells K562, with the IC(50) value of 2.20 microM.
TN1359	Aflatoxin G1 黄曲霉毒素G1,黄曲霉毒素 G1	TNF; NF-κB	Apoptosis; NF-κB
	Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce lung adenocarcinoma.
TN1872	Linderone	Others	Others
	Linderone A shows anticancer activity against A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line.
TN4352	Jatamanvaltrate B	Others	Others
	Jatamanvaltrate B shows cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8),and hepatoma (Bel7402) cell lines.
TN2492	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone	Others	Others
	1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans.
TN4355	Jolkinol A	Others	Others
	Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM.
TN3646	Chlorovaltrate K	Others	Others
	Chlorovaltrate K shows moderate cytotoxicity against lung adenocarcinoma (A 549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8) and hepatoma (Bel 7402) cell lines with IC50 values of 0.89-9.76 uM.
TN2493	1,4,5,6-Tetrahydroxy-7-prenylxanthone	Others	Others
	1,4,5,6-Tetrahydroxy-7-prenylxanthone has anti-cancer activity, it shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines; it also exhibits moderate activities with GI50 (Growth inhibitory) values of 2.
TN5249	Volvaltrate B	Others	Others
	Volvaltrate B shows cytotoxic activity against the lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines, with IC50 values of 8.5, 2.0, 3.2, and 6.1 uM, respectively.
TN3870	Iriflophenone 2-O-Rhamnoside Dimethylmatairesinol	Others	Others
	Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung c
T81452	Pixinol
	Pixinol，天然糖苷，对GLC4人肺癌细胞株和COLO 320腺癌细胞株显示出细胞毒性，IC50值分别为71 µM与43 µM。
TN2684	2,3,23-Trihydroxy-12-oleanen-28-oic acid	Others	Others
	2β,3β,23α-Trihydroxy-12-oleanen-28-oic acid shows cytotoxic activities to human lung adenocarcinoma(A-549)cell lines. 2α,3β,23-Trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibit cytotoxicity in vitro against the growth of human cancer cells lines HepG-2,with IC50 values of 16.13 ± 3.83, 15.97 ± 2.47 uM, respectively.
TN3009	4',5,7-Trihydroxy-6-prenylflavone	Others	Others
	6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. It also shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarci
TN4716	Oplodiol	Influenza Virus	Microbiology/Virology
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows moderate cytotoxic effects on the human
TN1646	Flemiphilippinin A	Others	Others
	Flemiphilippin A has antioxidant activity, it shows DPPH radical scavenging activity with effective half maximal concentration (EC50) of 18.36 ug/mL. Flemiphilippinin A (5 ug/mL) exhibits some level of antitumor activity against human hepatocellular carci
T81201	Sartorypyrone B
	Sartorypyrone B为Chevalone C的2β-乙酰氧基衍生物，由海绵源真菌Neosartorya tsunodae(KUFC 9213)的培养物中乙酸乙酯提取得到。该化合物对MCF-7、NCI-H460和A375-C5细胞系展示出较强的生长抑制活性，GI50s值分别为17.8、20.5和25.0 μM，显示其在乳腺癌、非小细胞肺癌和黑色素瘤研究中的应用潜力。

天然产物

Cat.No: TN5086

Target: Others

Cat.No: TN2347

Synonym: 麻醉椒苦素,Methysticin

Target: Others

Cat.No: T1660

Synonym: 水飞蓟宾 A,水飞蓟宾,Silibinin A,Silybin,Silymarin I

Target: Reactive Oxygen Species, Autophagy

Yunnancoronarin A

Cat.No: TN5274

Target: Others

Cat.No: TN1359

Synonym: 黄曲霉毒素G1,黄曲霉毒素 G1

Target: TNF, NF-κB

Cat.No: TN1872

Target: Others

Jatamanvaltrate B

Cat.No: TN4352

Target: Others

1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone

Cat.No: TN2492

Target: Others

Cat.No: TN4355

Target: Others

Chlorovaltrate K

Cat.No: TN3646

Target: Others

1,4,5,6-Tetrahydroxy-7-prenylxanthone

Cat.No: TN2493

Target: Others

Cat.No: TN5249

Target: Others

Iriflophenone 2-O-Rhamnoside

Cat.No: TN3870

Synonym: Dimethylmatairesinol

Target: Others

Cat.No: T81452

2,3,23-Trihydroxy-12-oleanen-28-oic acid

Cat.No: TN2684

Target: Others

4',5,7-Trihydroxy-6-prenylflavone

Cat.No: TN3009

Target: Others

Cat.No: TN4716

Target: Influenza Virus

Flemiphilippinin A

Cat.No: TN1646

Target: Others

Sartorypyrone B

Cat.No: T81201

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